Structural and Signaling Roles of the Cytoskeleton in Health & Disease
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Genetic Predisposition Factors to Alzheimer Disease
There is currently no treatment for Alzheimer disease (AD), the most common form of senile dementia affecting ~47 million people worldwide...
Pathogenic Mechanisms in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron disease...
CA1 Hippocampus Maintenance, Function and Integrity
Abnormalities in the hippocampus are associated with neuropsychiatric diseases characterized by cognitive dysfunction...
From Mitotic Spindle to DNA Damage Response
The microtubule-associated protein TPX2 is well known for its roles in promoting spindle assembly and regulating mitosis...
Brain-Body interactions in the sexual dimorphism of Amyotrophic Lateral Sclerosis
Male individuals are more susceptible to develop ALS than female individuals. The disease onset is also earlier in males with more severe manifestations...
p600 Links Microtubules to the Endoplasmic Reticulum
Protein 600 is a humongous 600 kDa polypeptide with the unique function of transporting ER membranes on stabilized microtubules...
The Cytoskeleton in Epilepsy:
Cause, Consequence or Bystander?
Epilepsy is a chronic condition whose hallmark feature is the occurrence of spontaneous recurrent seizures, and is typically associated with comorbid conditions, including learning and memory deficits, anxiety and depression...
